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The Functional Medicine View of Rosacea Functional medicine recognizes rosacea as a condition involving multiple interconnected systems: Gut microbiome Immune system regulation Nervous system activation Histamine signaling Skin barrier integrity Inflammatory cytokines Instead of viewing rosacea only through a dermatologic lens, functional medicine evaluates why the inflammatory response has become dysregulated

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For example, PT cellsresponsible for ~70% of renal iron reabsorptionexpress high levels of iron transporters (DMT1 and TfR1) and ACSL4 (a key enzyme for PUFA incorporation into phospholipids), making them inherently more prone to ferroptosis than DT cells or podocytes