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[DOI] [PubMed] [Google Scholar] Nakamura H, Yoshimura K, McElvaney NG, et al

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and joint hypermobility, the authors highlighted issues with foot and hand deformities (including brachydactyly, piezogenic pedal papules, hallux valgus, broad feet), fatigue, and muscle pain and weakness

This process triggers the release of histamine, prompting flushing symptoms to develop rapidly