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Advancements in ART procedures necessitate the optimization of fertility treatments to increase success rates ( in vitro fertilization procedures ( Understanding the effects of melatonin on the reproductive system is essential for developing personalized treatment approaches for individuals facing fertility challenges ( In brief, we explore how melatonin biosynthesis and control affect human reproduction, particularly the timing of puberty, the menstrual cycle, follicle development, ovulation, and embryo implantation, seeking to fill the knowledge gap regarding melatonins involvement in human reproduction and its potential influence on ART ( We hypothesized that melatonin is crucial for the regulation and enhancement of human reproductive processes