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Over-expression of miR-17-92 in HUVECs can protect ECs from erastin-induced ferroptosis by targeting the zinc lipoprotein (A20)-acyl-CoA synthetase long-chain family member 4 (ACSL4) axis that could protect glutathione peroxidase 4 (GPX4) and inhibit ROS production (Xiao et al., 2019)

As such, it is difficult to currently ascertain if the FhGST-S1 is acting in the same way as the Ov GST1

however, more evidence from well-designed, randomized controlled trials is needed to confirm a role for riboflavin in the prevention of cataracts

This gap has led a growing number of people to look beyond the typical routetoward natural, science-informed alternatives