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Injectable administration places the intact hexapeptide into subcutaneous adipose tissue, where it diffuses slowly into nearby capillaries and enters systemic circulation without encountering hepatic enzymes first

Screening for potential serum biomarkers in rat mesangial proliferative nephritis

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An increase in the nuclear translocation of CaMKIV/CREM decreases GPX4, which is accompanied by an increase in intracellular lipid-ROS, eventually leading to neutrophil iron apoptosis (170) ( Figure 3 )