Bax protein is a proapoptotic member that acts by forming pores on the mitochondrial outer membrane, allowing cytochrome c to translocate into the cytoplasm, resulting in the loss of energy production and the activation of proteolytic cascade leading to apoptosis (Westphal et al., 2014)
Am J Clin Pathol 123:125131
You may have the same thought I had when a client mentioned this to me What on earth is that? and, Is it a secret sleep potion? Well, buckle up, because were about to dive deep into this fascinating molecule
The GCH1/BH4 pathway acts as an endogenous antioxidant pathway, GCH1 protects cells from ferroptosis primarily through the antioxidant action of BH4, and is completely independent of GPX4-mediated protection against ferroptosis [44]
Additionally, a recent research study investigates how 4-Octyl itaconate (OI), a form of itaconate functioning as a KEAP1 inhibitor, affects DSS-induced UC in mice (264)