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Furthermore, high doses of melatonin have potential antioxidant effects, with speculative benefits in neurodegenerative diseases [42, 43]

13 , 1053330 (2022 Fan, L

PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer

Galectin-1 favors tumor growth by impairing the anti-tumor effects of NK cells

Taken together, these observations suggest that depending on the host species, the tissue of origin and the cytokine signature of the TME, NK cells can be manipulated to acquire a pro-tumoral and pro-angiogenic phenotype