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Glutathione is often called the "master antioxidant" because it is found in high concentrations in nearly every cell in the body

Histopathology revealed decreased expressions of TNF- and TGF-, inflammatory markers and fibrotic mediators

Thus bilirubins ability to scavenge ROS gives it an inhibitory function on cancer development and cancer-related inflammation

Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer AM et al (2012) Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Obeticholic acid (OCA), the most extensively studied FXR agonist, was evaluated in the FLINT trial (NCT01265498), where non-cirrhotic NASH patients receiving 25 mg daily for 72 weeks experienced notable improvements in liver histology, including reductions in steatosis, inflammation, and fibrosis [65,66,67,68]