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Witzel S, Maier A, Steinbach R, Grosskreutz J, Koch JC, Sarikidi A, et al

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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

Published research discloses that diminished sensory and motor nerve conduction velocities initiate different signs and symptoms related to peripheral DN, which include numbness induced by chronic hyperglycemia (Edwards et al., 2008)