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However, the lack of effect on total nicotine exposure indicates VLNC noncompliance, suggesting that smokers with SMI may respond to a reduced-nicotine standard by substituting alternative forms of nicotine." "Additional doseresponse relationships have been detected on the number of cigarettes smoked per day when low and high nicotine Spectrum cigarettes are available

Cigarette butts are still the most commonly littered item

Germany is one of the largest markets for next generation cigarettes in Europe due to the evolution of public attitudes and increasing acceptance of alternative tobacco products

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