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Kaeser PS, Regehr WG (2017): The readily releasable pool of synaptic vesicles

This was exemplified here by the fact that increased GSH production in the presence of 5-FOA (counter-selective for URA3 expression) appeared to be a non-specific response to 5-FOA, evident also in the control strain expressing URA3 behind pURA3 , rather than selection based on phenotypic heterogeneity as intended in this proof-of-principle study

Animal-to-human amount translation is not straightforward and requires allometric scaling, and human pharmacokinetics, safety, and efficacy remain uncharacterized in published literature

doi: 10.1038/s41380-022-01802-5 3 AlamM

In fact, it can create DNA strand breaks caused by the formation of NO-dependent reactive species such as peroxynitrite, which directly attack the DNA and cause failure to correct single-strand breaks, leading to the formation of double-strand breaks, which are probably responsible for cell death