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Impairment of thymusdependent immune functions by exposure of the developing immune system to 2, 3, 7, 8tetrachlorodibenzopdioxin (TCDD)

In view of these mechanisms, combination therapy strategies can overcome drug resistance through multitarget synergy, regulating the TME, overcoming redox homeostasis, improving drug efficacy, and effectively reversing drug resistance

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This is due to Met's ability to block oestradiol synthesis and aromatase expression in the testes, repair the ultrastructure of seminiferous tubules, and sustain LH/hCG-R expression in testicular Leydig cells []