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To recycle the disulfide, known atypical 2-Cys PRXs appear to use Trx as an electron donor

The Glutathione Supplementation Challenge Given glutathione's critical importance, supplementation seems like an obvious solution

Pediatr Res 14:11271131 Matsuishi T, Stumpf DA, Seliem M, Eguren LA, Chrislip K (1991) Propionate mitochondrial toxicity in liver and skeletal muscle: acyl CoA levels