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In the 80 participants, 12-week study, phenylethyl resorcinol was combined with three other actives (disodium glycerophosphate, L-leucine, and undecylenoyl phenylalanine) and only 57% of the participants showed at least a moderate response and 17% did not improve at all

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Nature , 551 (7682), 639643

Skin lightening therapy works by reducing excess melanin production, breaking down existing pigmentation, and improving cell turnover

The trial was registered with the Iranian Registry of Clinical Trials on 25/12/2019 ( registered code: IRCT20120718010333N5)