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It is separated from Apocynum cannabinum root and Picrorhiza kurroa Royle ex Benth , a traditional medicinal plant, that belongs to the Scrophulariaceae family (Nwokocha et al

Biochemically, ferroptosis is indicated by the inhibition of cystine/glutamate antiporter (System Xc ), the depletion of glutathione (GSH), decreased activity of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LOOH), and a decline in mitochondrial membrane potential (Mao et al., 2021

doi: 10.1161/JAHA.119.014044 224 PrakashRWaseemASiddiquiAJNaimeMKhanMARobertsonAAet al

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This was evidenced biochemically, micro- and macroscopically