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T.PernoC

Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically

Ethics All animal experimental protocols in this study were approved by the University of Zurich Animal Protection Office and Ethics committee, the Cantonal Veterinary Office of the Canton of Zurich (licences n 102/2018 and 136/2021), and conform to Swiss Animal Protection guidelines and regulations (Swiss Animal Protection and Swiss Animal Act and Ordinance) and in accordance with the EU Directive on the protection of animals used for scientific purposes

LWT 199, 116083