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7t) and offer a previously unappreciated view for future studies to determine whether pre-symptomatic changes involving the glutathioneascorbate metabolism pathway, particularly GSTO2, occur in cell types vulnerable to neurodegenerative conditions such as HD or SCAs

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Abbreviations: AA: arachidonic acid

Further research demonstrates that MPs activate hypoxia-inducible factor 1-alpha (HIF-1) expression in mouse TM3 Leydig cells and testicular tissue via the extracellular signal-regulated kinase 1/2 (ERK1/2)/MAPK and AKT pathways, down-regulating steroidogenic acute regulatory protein (StAR) expression