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Semaglutide carries a boxed warning and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2 syndrome

Proposed mechanisms include fibroblast migration and proliferation, modulation of growth-factor signalingincluding EGF and VEGFand changes in reticulin and collagen-fiber formation at injury sites

The staff reviewers said there is insufficient evidence of the safety and efficacy to support allowing compounding pharmacies to manufacture the peptides, citing limited human studies

Schedule: Daily subcutaneous injections for 812 weeks (extend to 16 weeks if needed)

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