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Sosne G, Szliter EA, Barrett R, Kernacki KA, Kleinman H, Hazlett LD

A: Research indicates GHK-Cu acts through multiple pathways including TGF- receptor upregulation, integrin expression modulation, and direct fibroblast stimulation

Although this mechanism by which zonulin dysregulates tight junctions has been well described thus far, it is important to note the controversy around EGFR localization within the apical membrane of intestinal epithelial cells and the implications this controversy may have on this specific mechanism

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Dialogues Clin Neurosci 8:383395