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Impaired signaling together with DNA damage and oxidative stress could be responsible for the persistent activation of pro-inflammatory cytokines, insulin resistance, and hepatic fibrogenesis [106]

Assessment of Smoking Exposure and Covariates Smoking information was self-reported and included age at initiation, current or former smoking status, and cumulative exposure in pack-years, defined as the product of packs of cigarettes smoked per day and the number of years smoked

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