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This setup gives researchers a practical way to study angiogenic upregulation, cytoskeletal dynamics, and extracellular matrix (ECM) remodelling all at once, rather than running separate isolated assays

Animal studies have suggested its potential in supporting tissue repair processes in muscle, tendon, and torn ligaments

Additionally, it exhibits multiple biological functions, including immunomodulation and promotion of wound healing [19]

J Adhes Sci Technol

Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols