For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress ( in situ GSH in tumor triggered mCMSNs biodegradation and reduced Cu 2+ into Cu + for enhanced hydroxyl radical production, leading to a powerful inhibition effect on tumors (Liu et al., 2019)
Deng J, Huang JC, Xu ZJ, Liu Y, Karrow NA, Liu M, et al
Some medications produce edema
[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Krezel A., Maret W
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