Unlike SLC25A1 inhibitors that remain in the preclinical research stage, the ACLY inhibitor bempedoic acid has been approved by the FDA as a new lipid-lowering drug
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Subsequent increases in the permeability of the intestinal barrier in CKD patients promote the translocation of bacterial products of intestinal origin, such as LPS, uremic toxins, and cytokines, into the systemic circulation, resulting in local and systemic inflammation, as well as oxidative stress associated with CKD (Krukowski et al., 2023
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