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The challenges of the treatment of addictive substances include managing long-term brain changes, addressing co-occurring mental health disorders, and overcoming social stigma that prevents individuals from seeking help

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This work also has other important strengths over previous studies including the sample size, length of intervention, multiple toxicant exposure measures and control conditions. The question of whether an e-cigarettes nicotine delivery profile is predictive of its ability to reduce harm and promote behavior change among smokers remains highly relevant to policymakers, public health advocates, health care providers and smoking populations

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