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Serious adverse events are rare, and the drug was well-tolerated even at the highest studied doses

Reduces the expression of cyclooxygenase-2 (COX-2)

Acute kidney injury due to volume depletion has been reported in postmarketing reports occurring in patients who experienced nausea, vomiting, or diarrhea, leading to dehydration

5-MTHF is then used in another chemical cycle called the methionine cycle , which is important for making proteins, methylation reactions, and regulating blood levels of homocysteine an amino acid linked to cardiovascular disease

The transformation of HCy into cysteine is catalyzed by the enzymes CBS and CSE as part of the trans- sulfuration pathway (Figure 2)