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The GLUD1 product -ketoglutarate was shown to be metabolized in the citric acid cycle to malate, which was shown to be exported from the mitochondrial matrix and converted to fumarate that was shown to bind and activate glutathione peroxidase 1 (GPX1), which detoxifies H 2 O 2 ( C

It's a balance between being localized and allowing for proper absorption

International Journal of Obesity, 32 (1), 6172

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Potential Side Effects of B12 Injections Most side effects are mild and temporary: Pain, redness, or swelling at the injection site