When activated the HGF/Met system has been shown to stimulate mitogenesis, motogenesis, morphogenesis and protect against tissue insults in several cellular targets including epithelial, endothelial, and neurons
Co-authors of the study include Sehyoun Yoon, PhD, research assistant professor of Neuroscience, Jeffrey Burgdorf, PhD, adjunct professor of Biomedical Engineering at the McCormick School of Engineering, Marc Dos Santos, PhD, a postdoctoral fellow in the Penzes laboratory, and Joseph Moskal, PhD, professor of Biomedical Engineering at the McCormick School of Engineering
Monitor: Resting heart rate increases above 90
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Fosgonimeton failed its Phase 2 ACT-AD trial in 2022 and its Phase 2/3 LIFT-AD trial in September 2024
