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In pathogenesis, apoptosis and inflammation are important processes that drive the progressive destruction of thyroid tissue

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This means even systemic abdominal injections can support localized repair at distant injury sites, though local injection near the injury may provide higher concentrations at the target area

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[1] Other manifestations of B12 deficiency include glossitis (sore, red tongue), mouth ulcers, visual disturbances, and in severe cases, psychiatric symptoms such as depression, psychosis, or dementia-like presentations