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In many regions, untaxed, counterfeit, and smuggled cigarettes dominate, often originating from a small number of source countries and moving along established routes

Lung cancer is the leading cause of cancer death among men and the second most common fatal cancer in women, comprising 21.5 and 13.7% of all cancer deaths, respectively.1,2 Tobacco consumption is the main association factor of this disease followed by exposure to indoor radon.2 Radon is classified as the main cause of lung cancer in never smokers and the second most common in ever-smokers by the United States Environmental Protection Agency (USEPA) and the World Health Organization (WHO).35 The molecular mechanism of radon carcinogenesis is not fully understood, and lack of knowledge remains regarding the precise molecular carcinogenic pathways for tobacco exposure

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however, it is typically recognized by the constellation of long limbs, aortic root dilation, and dislocated lenses