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Inside cells, most of the glutathione (8590%) is in the cytosol where it primarily exists in a reduced form (GSH) and to a much lesser extent as an oxidized disulfide form (GSSG)

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The structure-functional properties of these 5 specific viral-hijacked host cellular factors, their ultimate pathophysiological consequence(s) due to virus-induced HMRD in acute COVID-19 and during long-COVID, the persistent virus-free PASC disease state, is comprehensively described below