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8388 A completed Phase I/IIA multicenter dose-ranging clinical trial that sought to assess the safety and efficacy of TLK286 found that the compound was highly efficacious

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doi: 10.1038/s42255-022-00550-8 28 MacMickingJXieQWNathanC

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Many studies show the important role exerted by GSH in DNA synthesis and cell proliferation [14], regulation of the nuclear matrix organization [15] and maintenance of cystine residues on zinc-finger DNA-binding motifs in a reduced and functional state [16]

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We next examined the localization of tubulin to assess abnormal spindle formation, which is closely associated with chromosome mis-segregation (Fig

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