The findings of murine studies should be interpreted in the context of the fact that humans are diurnal (activity occurs during daytime), and mice are nocturnal (activity occurs during nighttime)
Histopathological analysis and immunohistochemical staining revealed decreased expression of K16, K17, and Ki67 in SFN-treated mice, indicating reduced abnormal differentiation of keratinocytes and cutaneous inflammation
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A biomarker is defined as a characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions
In addition, a single case report described that a 10-year-old ASD child who received microgranules including palmitoylethanolamide and luteolin twice a day for one year showed an improvement in ASD-like behaviors [100]
