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In fact, reduced glutathione is the biologically active form that can be directly utilized by the human body, exerting important functions such as acting as an antioxidant and facilitating detoxification
Thus, increasing antioxidant capacity would limit adaptation to stress incurred during aging
Consistent with this, we found that hepatic GSH level fell more than 50% following LPS, coinciding with a comparable fall in the mRNA and protein levels of GCLC and GCLM (5060%) [163]