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Frailty, measured by the Short Physical Performance Battery, classified 22.5% as severely frail, 29.5% frail, 28% pre-frail, and 20% robust

If we assume that morphine and DAMGO stabilize different conformations of the MOPr, which can both couple to G proteins and activate the G protein-coupled inwardly rectifying K + channel, yet have different affinities for PKC versus GRK2, then this could explain these data

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