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In human studies, statistical differences between Control and HyperSperm groups were analyzed using Wilcoxon matched-pairs signed rank test for safety analysis, Fishers exact test for fertilization and embryo development, or a log-rank test (Mantel-Cox) for developmental times

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They found at three weeks there was a better effect with the corticosteroid group compared to the Hyaluronan and placebo but by 26 weeks there was no difference between Hyaluronan, placebo or corticosteroids

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They interact closely with nerve cells within the enteric nervous system (ENS), the second brain that governs gut motility, emotion, and inflammation