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These tissues are considered to be the last to decrease their thiamine content during TD and the first to replete it upon thiamine administration, with the liver serving as the thiamine depot for other tissues (156)

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It also leads to an improved performance

Personalized treatment and metabolic response modulation: from organoids to real-time treatment adjustment With the advancement of personalized medicine, CRC treatment strategies are gradually shifting from traditional molecular subtyping toward metabolic subtyping

& Fernyhough, P