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Preparation and functional evaluation of RGD-modified proteins as v3 integrin directed therapeutics

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Quickstart Highlights PE-22-28 is a synthetic heptapeptide (sequence GVSWGLR) corresponding to residues 2228 of spadin , the propeptide of sortilin, and acts as a potent, selective blocker of the TREK-1 (KCNK2) potassium channel [1] [2]