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Site rotation: Move between abdomen, thighs and upper arms to reduce local irritation and lipohypertrophy [12]

The results showcased an average decrease in body fat percentage, particularly around the abdominal area, highlighting its targeted action

### Semaglutide Mechanism of Action Semaglutide achieves **weight loss** through multiple complementary pathways: - **Central appetite suppression** acts on hypothalamic GLP-1 receptors to reduce hunger and increase satiety - **Delayed gastric emptying** slows stomach emptying, prolonging feelings of fullness - **Improved insulin sensitivity** reduces insulin resistance and promotes healthy glucose metabolism - **Reward pathway modulation** reduces cravings and food-seeking behavior by acting on mesolimbic dopamine circuits - **Potential direct effects on adipose tissue** emerging research suggests GLP-1 may directly influence fat metabolism For a complete breakdown of semaglutide's dosing protocol, see our [semaglutide dosing schedule week-by-week guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)

While our skilled providers at Your Skin Prescription will always choose the ideal site for you, knowing your options can help you feel more prepared and confident

doi: 10.1208/s12248-013-9465-7