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Additional information Competing interests Boston University has intellectual property related to the work described in this manuscript

Similarly, nanoparticle-induced ROS can activate NLRP3 inflammasomes, enhancing phagocytic clearance of pathogens

That seems to be significant, but no one's really kind of discussing it

Consequently, cationic CPPs, which are better suited for cellular uptake owing to their positive charge, are more effective for the cellular delivery of CAND

However, if the FDA ultimately reclassifies them and they are produced by compounding pharmacies in the U.S., clinicians would have discretion to write prescriptions outside of those narrow indications