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Unlike TET deficiency, knockdown of ALKBH1 or ALKBH5 did not reduce YBX1 or AMPK levels in Huh7 and H1299 cells (Supplementary Fig

(2024) 80:e76e7

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it may ameliorate insulin resistance, inflammation, and protein wasting. Despite the body of evidence to support its use the authors somehow conclude LC administration continues to appeal to nephrologists because its use in dialysis patients has an attractive rationale, it addresses problems that persist despite dialysis, it is safe, and the existing literature does not refute its use