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A 2005 study demonstrated that both peptide and non-peptide GH secretagogues act through the GHS-R1a receptor but can also function as ghrelin receptor ligands with distinct binding properties, suggesting potential differences in downstream signaling despite shared receptor engagement

Bakshi RK, Patel GF, Rasmusson GH, Baginsky WF, Cimis G, Ellsworth K, et al

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Numerous studies have shown conflicting results, with many showing no added benefit from supplementing L-carnitine during a dieting phase

10.1038/s42255-022-00591-z 114 NacarelliT.FukumotoT.ZundellJ