This oxidative burst serves dual roles: while moderate ROS levels activate antiviral signaling, excessive ROS production triggers mitochondrial permeability transition, mtDNA release, and cell death (Kayesh et al., 2025)
Cellular effects, uptake, and permeability of the nanoparticles were investigated on a human stem cell-based co-culture BBB model with improved barrier properties induced by a small molecular cocktail
163 As an example, Tiriveedhi et al reported that lung transplant patients, who developed chronic lung allograft rejection, show increased defensin and decreased serum AAT levels along with high concentrations of AAT-defensin complexes in their bronchial lavage
Novinscak, T., Brcic, L., Staresinic, M., Jukic, I., Radic, B., Pevec, D., et al
Chinen, Lori