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SCA3 is also characterized by dysfunction of the pyramidal tract, manifesting as spasticity and hyperreflexia, which is variably associated with peripheral muscular atrophy and/or other motor-related clinical manifestations such as parkinsonism, dysarthria, nystagmus, dystonia, and external progressive ophthalmoplegia

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An unblinded trial suggested that cyclosporine could be safely used in combination with adalimumab and that the combination was more effective than either drug alone

LawtonJSTamis-HollandJEBangaloreSBatesERBeckieTMBischoffJMet al2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American college of cardiology/American heart association joint committee on clinical practice guidelines