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It is primarily studied for its role in modulating mitochondrial function and metabolic homeostasis

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In NSCLC, recent reports suggest that human lung cancer cell growth can be inhibited by GPX4-related ferroptosis, a type of cell death characterized by lethal accumulation of lipid-based ROS 17,18

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From that biology, researchers draw a theoretical concern: chronically potentiating a proliferative, pro-angiogenic pathway is a plausible mechanism by which an agent could, in principle, support growth of existing malignancy