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Untargeted metabolomics analysis by UHPLC-MS/MS
Similarly, a randomised control trial in older adults with median age 73 years reported that supplementation of 500 mcg vitamin B12, 400 mcg folic acid and 15 mcg vitamin D3 for two years resulted in an average reduction of homocysteine by approximately -4.2 micro mol/L compared to the placebo group (De Koning et al, 2016)
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Second, the niosomal bilayer structure enables controlled and sustained drug release, as the vesicles gradually release their cargo over an extended period rather than releasing it all at once [122,124]
