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2011, Jan, 22;45(1):10109 Alderson NL, Wang Y, Blatnik M, Frizzell N, Walla MD, Lyons TJ, et al

Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S

This work was supported by the Loterie Romande and the Fonds pour la Recherche en Sant du Qubec (SL)

PMID: 109 Al-ShuhaibMBSAl-ShuhaibJMB

Oncolytic CVA21 production was scaled-up 75-fold from the laboratory scale and demonstrated across seven batches in 250 L single-use microcarrier bioreactors and purified with customized, prepacked, single-use 1.5 L GSH affinity chromatography columns