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Apoptotic bodies are frequently phagocytosized by adjacent normal cells including hepatocytes and macrophages

Emerging evidence indicates that gut microbiota and their metabolites directly modulate 5-HTR expression and function through multiple pathways ( Faecalibacterium prausnitzii , has been shown to enhance the expression of 5-HT1A receptors in intestinal epithelial cells via histone deacetylase (HDAC) inhibition, thereby promoting anti-inflammatory and anxiolytic effects ( 3.3.2 The impact of the microbiota on GABA receptors The gamma-aminobutyric acid receptor (GABAR) is a major inhibitory neurotransmitter receptor in the brain, crucial for regulating neural excitability and maintaining neural functional balance ( 3.4 The impact of the microbiota on immune regulation 3.4.1 Microbial metabolites regulate immune cell differentiation and function Gut microbiota and their metabolites play a pivotal role in shaping the plasticity of immune cells via multiple mechanisms, including direct metabolic effects, modulation of immune signaling pathways, and epigenetic modifications

Review article: the current management of acute liver failure

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Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells