doi: 10.1155/2013/183024 139 Escobar-MorrealeHFLuque-RamirezMAlvarez-BlascoFBotella-CarreteroJISanchoJSan MillanJL
Currently, treatments based on copper metabolism in cardiovascular disease can encompass a wide range of options, including copper chelating agents [such as triethylenetetramine (TETA), tetrathiomolybdate (TTM) and disodium ethylene diamine tetraacetic acid (EDTA)], small-molecule inhibitors of copper chaperone proteins (such as DCAL50), copper ion carriers and natural antidote agents (Table II)
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Previous animal studies have also detected reduced Hcy concentrations after creatine supplementation ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )
Neuroglial changes in physiological brain ageing are relatively subtle, with white matter being the most affected: in healthy old age, white matter volume is decreased by ~ 10%, whereas the grey matter is reduced by a mere 3%
