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Catherine Sampson, Sierra Miller, Kehinde Ogunseye, and Erika Main for help with technical aspects of this study, Dr
In a PCOS contextcharacterized by insulin resistance, oxidative stress, and neutrophil primingthe ability of metformin to reduce NETs may translate into diminished neutrophildriven inflammation, improved ovarian microenvironment, and lower systemic thromboinflammatory risk
Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide
EGb, Ginkgo biloba extract