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Between 2016 and 2024, publication activity remained generally low, with slight increases observed in 2019 and 2024 (seven articles each), suggesting sporadic periods of greater research interest ( Figure 2 )

In the future, with deeper understanding of gutliver axis mechanisms and the popularization of microbiome testing technologies, liver disease treatment will truly enter a new era of liver-gut combined therapy. Clinicians are expected to formulate integrated prescriptions containing traditional liver-targeted drugs and personalized intestinal niche management plans for each patient, thereby maximizing therapeutic benefits and achieving a fundamental shift from disease treatment to healthy ecological niche maintenance

Encourage them to eat B12-rich foods (meat, fish, dairy, eggs) when possible

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